Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence

S Whittle; JG Simmons; S Hendriksma; N Vijayakumar; ML Byrne; M Dennison; NB Allen

Journal article

Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence

S Whittle, JG Simmons, S Hendriksma, N Vijayakumar, ML Byrne, M Dennison, NB Allen

Brain and Behavior | WILEY | Published : 2017

DOI: 10.1002/brb3.607

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Abstract

Introduction: It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocampus. However, the hippocampus is a functionally and structurally heterogeneous region, and little is known about how maltreatment might affect hippocampal subregion development throughout important periods of plasticity. This study investigated whether childhood maltreatment was associated with the development of hippocampal subregion volumes from early to late adolescence. It also investigated associations between onset of psychiatric disorder and hippocampal subregion volume development. Methods: One hundred and sixty-six (85 male) adolescents took part in three ..

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University of Melbourne Researchers

Sarah Whittle Author

Julian Simmons Author

Nandita Vijayakumar Author

Nick Allen Author

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Grants

Awarded by Royal Children's Hospital Foundation

Funding Acknowledgements

Colonial Foundation; National Health and Medical Research Council (NHMRC), Grant/Award Number: 350241 and 1007716; Australian Research Council (ARC), Grant/Award Number: DP0878136 and DP1092637